Prevention and treatment of restenosis by local administration of drug

Abstract From the Canadian patent

Apolipoprotein A-I (ApoA-l), preferably a variant form such as Apolipoprotein A-l Milano (ApoA-lM), alone or more preferably in combination with a lipid carrier such as phospholipids or other drug can be administered locally , before or during bypass surgery on diseased coronary peripheral, and cerebral , arteries, surgery to implant grafts or transplanted organs or angioplasty, or , to stabilize unstable plaques. ln an alternative embodiment the , apolipoprotein is not provided directly but the gene encoding the , apolipoprotein is provided. The gene is introduced into the blood vessel in a manner similar to that used for the protein where the protein is then , expressed. The technique …