Methods of making glycolmolecules with enhanced activities and uses thereof

Abstract From the Canadian patent

Methods to rapidly produce and identify polysaccharides and other sugar , structures, having enhanced activities have been developed. The methods , include producing a molecule e.g. a therapeutic molecule, which includes a first, non-saccharide moiety (e.g. a protein polypeptide, peptide, amino , acid or lipid) and a second polysaccharide, moiety. The method includes: determining the chemical composition and structure of all or a portion of the second moiety, modifying the structure of the second moiety to provide a modified second moiety, and evaluating or screening the molecule having the modified second moiety, e.g. for a biological activity or other chemical or physical property. …