Process for preparing 5-sulfonamido-8-hydroxy-1, 6-naphthyridine-7-carboxamides
CA 2456155 A1 · Owner: Askin, David · Inventors: Askin, David; Maligres, Peter E.
Overview
Its claims, description and drawings are in the Canadian Patents Database.
Open the CIPO recordAbstract From the Canadian patent
The preparation of 5-sulfonamido-8-hydroxy-1,6-naphthyridine-7-carboxamides is disclosed. A 5-halo-8-hydroxy-1,6-napthyridine-7-carboxylic acid or acid ester in which the hydroxy is derivatized with a protecting group is reacted with a sulfonamide (e.g. an alkanesulfonamide N-alkyl alkanesulfonamide, or , alkanesultam) in the presence of a copper promoter and a chelating agent followed by deprotection of the hydroxy group and then coupling with an amine , to obtain the 5-sulfonamido-8-hydroxy-1,6-naphthyridine-7-carboxamide. Alternatively, the hydroxy-protected 5-halo-8-hydroxy-1,6-napthyridine-7carboxylic acid (or ester) is first coupled with an amine the resulting , carboxamide …
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Listed from its CIPO record in Patent Yard's archive of Canadian patents past their term. Its claims, description and drawings are in the CIPO record and on Google Patents, and the Claude kit works from them.
Why it's free to use
- Filed August 13, 2002. No grant is recorded for it in Canada; had it been granted, its 20-year term would have ended August 13, 2022.
- A certificate of supplementary protection adds at most two years for a drug, so even that would have ended by August 13, 2024.
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Timeline
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Sources & verification
Official CIPO records
Everything on this page comes from the CIPO record linked above. Contains information licensed under the Open Government Licence – Canada.