Microoroganisms and cells for diagnosis and therapy of tumors

Abstract From the Canadian patent

Described are diagnostic and pharmaceutical compositions containing a microorganism or cell for in vivo detection imaging and/or treatment of a , tumor, tumor tissue, cancer or metastasis in a subject. The microorganisms or cells provided, preferentially accumulate in tumors tumor tissues, cancers or metastases. For detection and imaging, the microorganisms or cells are modified to express that induces, a detectable signal, which can be detected externally to the subject. The microorganisms or cells provided also can be employed to treat a tumor tumor , tissue, cancer or metastasis and can be modified to express a protein for tumor therapy and/or, elimination of a metastatic tumor.