2-amino-4,5-trisubstituted thiazolyl derivatives and their use against autoimmune disorders

Abstract From the Canadian patent

This invention concerns the use of a compound of formula (I') a N-oxide, a , pharmaceutically acceptable addition salt a quaternary amine and a , stereochemically isomeric form thereof wherein Z is halo; C1-6alkyl; C1-6 , alkylcarbonyl; C1-6alkyloxycarbonyl; aminocarbonyl; C1-6alkyl substituted with hydroxy, carboxyl, cyano, amino, amino substituted with piperidinyl amino , substituted with C1-4alkyl substituted piperidinyl mono -or di(C1-, 6alkyl)amino, aminocarbonyl mono -or di(C1-6alkyl)aminocarbonyl, C1- 6alkyloxycarbonyl, C1-6alkyloxy, piperidinyl piperazinyl, morpholinyl, thiomorpholinyl; polyhaloC1-4alkyl; cyano; amino; mono -or di(C1- 6alkyl)aminocarbonyl; C1-6alkyloxycarbonyl; …