Novel process for preparing rac-bicalutamide and its intermediates
CA 2448571 A1 · Owner: Reany, Ofer · Inventors: Dolitzky, Ben-Zion; Reany, Ofer; Shammai, Jenny
Overview
Its claims, description and drawings are in the Canadian Patents Database.
Open the CIPO recordAbstract From the Canadian patent
The present invention relates to a new process for the synthesis of racemic and optically active bicalutamide starting from ethyl pyruvate and methyl methacrylate. The present invention discloses processes of preparing bicalutamide intermediates including ethyl-2-{4-fluorophenyl sulfone}-2hydroxy propionate, 1,2-epoxy-2-methyl propionate and 2-hydrox-2-methyl-3-(4fluorophenylthio) propionic acid. The present invention further discloses micronized rac-bicalutamide and the preparation thereof.
Read the whole patent
Listed from its CIPO record in Patent Yard's archive of Canadian patents past their term. Its claims, description and drawings are in the CIPO record and on Google Patents, and the Claude kit works from them.
Why it's free to use
- Filed June 13, 2002. No grant is recorded for it in Canada; had it been granted, its 20-year term would have ended June 13, 2022.
- A certificate of supplementary protection adds at most two years for a drug, so even that would have ended by June 13, 2024.
- We check Canadian rights only. A patent in its family in another country could still be in force: check its family on Google Patents.
Timeline
Timeline From CIPO dates
Sources & verification
Official CIPO records
Everything on this page comes from the CIPO record linked above. Contains information licensed under the Open Government Licence – Canada.