A process for preparing paroxetine hci which limits formation of pink colored compounds
CA 2447808 A1 · Owner: Pilarski, Gideon · Inventors: Pilarski, Gideon; Avrutov, Ilya
Overview
Its claims, description and drawings are in the Canadian Patents Database.
Open the CIPO recordAbstract From the Canadian patent
The present invention provides a process for preparing paroxetine HCl from paroxetine base which provides paroxetine HCl substantially free of pinkcolored compounds or an impurity identified by an HPLC RRT of about 1.5. The processes of the present invention utilize a buffer a molar ratio of HCl to , paroxetine base of less than one and crystallize/recrystallize in the , presence of an effective amount of an anti-oxidant. A preferred way to create a buffer is by using ammonium chloride. A preferred anti-oxidant is ascorbic acid. The present invention also provides for re-crystallizing paroxetine HCl prepared by the above methods or any other methods in the presence of an effective …
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Listed from its CIPO record in Patent Yard's archive of Canadian patents past their term. Its claims, description and drawings are in the CIPO record and on Google Patents, and the Claude kit works from them.
Why it's free to use
- Filed June 14, 2002. No grant is recorded for it in Canada; had it been granted, its 20-year term would have ended June 14, 2022.
- A certificate of supplementary protection adds at most two years for a drug, so even that would have ended by June 14, 2024.
- We check Canadian rights only. A patent in its family in another country could still be in force: check its family on Google Patents.
Timeline
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Sources & verification
Official CIPO records
Everything on this page comes from the CIPO record linked above. Contains information licensed under the Open Government Licence – Canada.