Methods for the identification of antiviral compounds

Abstract From the Canadian patent

The present invention provides novel methods for determining whether a compound influences a phase in the life cycle of a virus comprising providing a cell with said compound and with at least a fragment of said virus sufficient for performing said phase and determing whether said phase is influenced in said cell, said cell comprising a nucleic acid encoding an adenovirus early protein or a functional part derivative and/or analogue of , said adenovirus early protein. In another aspect the invention provides the use of a cell, said cell comprising nucleic acid encoding an adenovirus early protein, for screening a library of compounds for the presence of a compound capable of …