Preparation of warfarin sodium from warfarin sodium-2-propanol clathrate by solvent expulsion
CA 2439489 A1 · Owner: Taro Pharmaceutical Industries Ltd. · Inventors: Ulanenko, Konstantin; Chernyak, Shimon; Bercovici, Sorin
Overview
Its claims, description and drawings are in the Canadian Patents Database.
Open the CIPO recordAbstract From the Canadian patent
The present invention is a method for producing warfarin sodium from warfarin sodium 2-propanol clathrate by thermal nondestructive solvent expulsion. The solvent expulsion is conducted under conditions of controlled heat transfer whereby the 2-propanol is expelled from the warfarin sodium 2-propanol clathrate without decomposition of warfarin sodium or the clathrate. Heating is conducted the clathrate at a temperature from about 100 ~C to about 170 ~C in an active oven under air or in an inert atmosphere and at partial pressures ranging from that of a relative vacuum to atmospheric pressure. The invention also relates to pure warfarin sodium prepared according to the method of the …
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Listed from its CIPO record in Patent Yard's archive of Canadian patents past their term. Its claims, description and drawings are in the CIPO record and on Google Patents, and the Claude kit works from them.
Why it's free to use
- Filed December 28, 2001. No grant is recorded for it in Canada; had it been granted, its 20-year term would have ended December 28, 2021.
- A certificate of supplementary protection adds at most two years for a drug, so even that would have ended by December 28, 2023.
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Official CIPO records
Everything on this page comes from the CIPO record linked above. Contains information licensed under the Open Government Licence – Canada.