Mutation detection using muts and reca
CA 2439098 A1 · Owner: Wagner, Robert E. Jr. · Inventors: Radman, Miroslav; Wagner, Robert E. Jr.
Overview
Its claims, description and drawings are in the Canadian Patents Database.
Open the CIPO recordAbstract From the Canadian patent
A method for detecting mutations and polymorphisms including single , nucleotide polymorphisms (SNP's) is based on the use of RecA-like recombinase protein and a MutS-like mismatch binding protein. RecA coated specific DNA , oligonucleotide probes (RecA filaments) are used for homology searching in duplex DNA. Location of homologous sequences results in the formation of Dloop structures containing a duplex region comprised of the oligonucleotide probe and one strand of the test DNA. Mismatches or unpaired bases in the duplex region are substrates for MutS binding. Co-localization of MutS and oligonucleotide or RecA labels is diagnostic of specific sequence differences between the …
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Listed from its CIPO record in Patent Yard's archive of Canadian patents past their term. Its claims, description and drawings are in the CIPO record and on Google Patents, and the Claude kit works from them.
Why it's free to use
- Filed February 20, 2002. No grant is recorded for it in Canada; had it been granted, its 20-year term would have ended February 20, 2022.
- A certificate of supplementary protection adds at most two years for a drug, so even that would have ended by February 20, 2024.
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Everything on this page comes from the CIPO record linked above. Contains information licensed under the Open Government Licence – Canada.