Attenuated pasteurellaceae bacteria and an anti-bacterial vaccine prepared therefrom

Abstract From the Canadian patent

Gram negative bacterial virulence genes are identified thereby allowing the , identification of novel anti-bacterial agents that target these virulence genes and their , products, and the provision of novel gram negative bacterial mutants useful in vaccines. The bacteria, which are Pasteurella bacterium of the Pasteurellaceae bacterial family selected from Pasteurella (Mannheimia) haemolytica Actinobacillus pleuropneumoniae and Haemophilus somnus are attenuated by a , mutation in the polynucleotide sequence that encodes an atpG polypeptide. The attenuated bacteria are useful in the prevention of disease manifestations following , infection including septicemias bronchopneumonias, …