Process for the preparation of phosphorothioate oligonucleotides
CA 2437040 C · Owner: Mellor, Ben James · Inventors: Douglas, Mark Edward; Wellings, Donald Alfred; Mellor, Ben James
Overview
Its claims, description and drawings are in the Canadian Patents Database.
Open the CIPO recordAbstract From the Canadian patent
A process for the synthesis of phosphorothioate oligonucleotides is provided which comprises assembling an aligonucleotide bound to to a solid support in the presence of acetonitrile; prior to cleaving the oligonucleotide from the solid support removing the acetonitrile; and cleaving the oligonucleotide from the solid support. The process is particularly suited to the large scale synthesis of nucleotides. The acetonitrile may be removed from the solid support by one or both to drying and by washing with solvents. Preferred washing solvents comprise trialkylamines.
Read the whole patent
Listed from its CIPO record in Patent Yard's archive of Canadian patents past their term. Its claims, description and drawings are in the CIPO record and on Google Patents, and the Claude kit works from them.
Why it's free to use
- Filed December 3, 2001 and granted January 25, 2011. A Canadian patent filed from October 1, 1989 lasts 20 years from filing, so its term ended December 3, 2021.
- A certificate of supplementary protection adds at most two years for a drug, so even that would have ended by December 3, 2023.
- We check Canadian rights only. A patent in its family in another country could still be in force: check its family on Google Patents.
Timeline
Timeline From CIPO dates
Sources & verification
Official CIPO records
Everything on this page comes from the CIPO record linked above. Contains information licensed under the Open Government Licence – Canada.