Jfy1 protein induces rapid apoptosis
CA 2432111 A1 · Owner: Yu, Jian · Inventors: Vogelstein, Bert; Kinzler, Kenneth W.; Yu, Jian
Overview
Its claims, description and drawings are in the Canadian Patents Database.
Open the CIPO recordAbstract From the Canadian patent
Through global profiling of genes that were expressed soon after p53 expression, we identified a gene termed (JFY1). The protein encoded by (JFY1) was found to be exclusively mitochondrial and to bind to Bcl-2 and Bcl-XL through a BH3 domain. Exogenous expression of (JFY1) resulted in an extremely rapid and profound apoptosis that occurred much earlier than that resulting from exogenous expression of p53. Based on its unique expression patterns p53-, dependence, and biochemical properties,(JFY1) is likely to be a direct mediator of p53-associated apoptosis.
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Listed from its CIPO record in Patent Yard's archive of Canadian patents past their term. Its claims, description and drawings are in the CIPO record and on Google Patents, and the Claude kit works from them.
Why it's free to use
- Filed December 12, 2001. No grant is recorded for it in Canada; had it been granted, its 20-year term would have ended December 12, 2021.
- A certificate of supplementary protection adds at most two years for a drug, so even that would have ended by December 12, 2023.
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Timeline
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Sources & verification
Official CIPO records
Everything on this page comes from the CIPO record linked above. Contains information licensed under the Open Government Licence – Canada.