P450rai-2 (p450 cytochrome 26b), encoding nucleic acid molecules and methods and uses thereof
CA 2431640 A1 · Owner: White, Jay A. · Inventors: Jones, Glenville; Petkovich, P. Martin; White, Jay A.
Overview
Its claims, description and drawings are in the Canadian Patents Database.
Open the CIPO recordAbstract From the Canadian patent
The present invention provides a novel all-trans-RA inducible all-trans-RA metabolizing cytochrome P450, P450RAI-2 that is predominantly expressed in , the brain cerebellum in particular. It is also expressed in normal and tumour lung tissue and in breast cancer cells and may have a correlation with lung and breast cancer. Human P450RAI-2 show 42% amino acid identity to human P450RAI-1 and when transfected into COS-1 cells causes the rapid conversion of all-trans-RA into more polar metabolites including the inactive products 4-oxo- RA, 4-OH-RA and 18-OH-RA. P450RAI-2, as with P450RAI-1 is also inducible in , certain cultured cell lines exposed to all-trans-RA. Methods for and uses of …
Read the whole patent
Listed from its CIPO record in Patent Yard's archive of Canadian patents past their term. Its claims, description and drawings are in the CIPO record and on Google Patents, and the Claude kit works from them.
Why it's free to use
- Filed December 17, 2001. No grant is recorded for it in Canada; had it been granted, its 20-year term would have ended December 17, 2021.
- A certificate of supplementary protection adds at most two years for a drug, so even that would have ended by December 17, 2023.
- We check Canadian rights only. A patent in its family in another country could still be in force: check its family on Google Patents.
Timeline
Timeline From CIPO dates
Sources & verification
Official CIPO records
Everything on this page comes from the CIPO record linked above. Contains information licensed under the Open Government Licence – Canada.