Characterization of grp94-ligand interactions and purification, screening, and therapeutic methods relating thereto
CA 2429196 A1 · Owner: Duke University · Inventors: Reed, Robyn C.; Nicchitta, Christopher V.; Wassenberg, James J.
Overview
Its claims, description and drawings are in the Canadian Patents Database.
Open the CIPO recordAbstract From the Canadian patent
The present invention discloses characterization of interactions between ligands and Hsp90 proteins, including GRP94 wherein ligand binding to the N-, terminal nucleotide binding domain of GRP94 elicits a conformational change that converts the GRP94 from an inactive to an active conformation and , wherein the chaperone and peptide-binding activities of the GRP94 are markedly stimulated. Also disclosed are purification screening, and therapeutic , methods pertaining to the biological activity of GRP94 and in some instances , HSP90, based upon the characterization of ligand interactions of Hsp90 peptidebinding proteins, including GRP94.
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Listed from its CIPO record in Patent Yard's archive of Canadian patents past their term. Its claims, description and drawings are in the CIPO record and on Google Patents, and the Claude kit works from them.
Why it's free to use
- Filed March 26, 2001. No grant is recorded for it in Canada; had it been granted, its 20-year term would have ended March 26, 2021.
- A certificate of supplementary protection adds at most two years for a drug, so even that would have ended by March 26, 2023.
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Timeline
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Official CIPO records
Everything on this page comes from the CIPO record linked above. Contains information licensed under the Open Government Licence – Canada.