Retiferol derivatives and their use in the treatment of skin diseases or conditions associated with photodamage

Abstract From the Canadian patent

Disclosed are retiferol derivatives of formula (I): wherein X is > C=CH2 or - CH2-; Y and Z are independently of each other hydrogen fluorine or hydroxy; A , is -O(CH2)3-, -(CH2)2-(1,2-C6H4)- -CH=CH-(1,2-C6H4)-, -C=C-(1,2-C6H4)-, - (CH2)2-CO-, -CH2-O-CO-, -CH2NHCO-, or -CH2NHCOCH2-; R1 is C1-C5-alkyl; R2 and R3 are independently of each other alkyl or perfluoroalkyl; and R4 is hydrogen, hydroxy, C1-C5-alkyl or C1-C5-alkyl or C1-C5-alkoxy; the use of such compounds to treat or present hyperproliferative skin diseases such as psoriasis, basal cell carcinomas, disorders of keratinization and keratosis; neoplastic diseases; disorders of the sebaceous glands such as acne and seborrhoic …