Synthesis of pancrastistatin
CA 2427449 A1 · Owner: Arizona Board Of Regents, A Body Corporate Of The State Of Arizona Actin G For And On Behalf Of The Arizona State University · Inventors: Melody, Noeleen; Pettit, George R.
Overview
Its claims, description and drawings are in the Canadian Patents Database.
Open the CIPO recordAbstract From the Canadian patent
Narciclasine (2), available in quantity from certain Amaryllidaceae species or by total synthesis, is employed as relay for a ten step synthetic conversion (3.6 % overall yield) to natural (+)-pancratistatin (1a). The key procedures involve the epoxidation of natural (+)-narciclasine (2) to an epoxide (6), reduction of the epoxide (6) to diol (8) formation of cyclic , sulfate (12) and its ring opening with cesium benzoate followed by saponification of the benzoate to afford (+)-pancratistatin (1a).
Read the whole patent
Listed from its CIPO record in Patent Yard's archive of Canadian patents past their term. Its claims, description and drawings are in the CIPO record and on Google Patents, and the Claude kit works from them.
Why it's free to use
- Filed December 20, 2001. No grant is recorded for it in Canada; had it been granted, its 20-year term would have ended December 20, 2021.
- A certificate of supplementary protection adds at most two years for a drug, so even that would have ended by December 20, 2023.
- We check Canadian rights only. A patent in its family in another country could still be in force: check its family on Google Patents.
Timeline
Timeline From CIPO dates
Sources & verification
Official CIPO records
Everything on this page comes from the CIPO record linked above. Contains information licensed under the Open Government Licence – Canada.