Hydrolysis of r(r*,r*)-2-(4-fluorophenyl)-.beta..delta. -dihydroxy-5-(1-methylethyl)-3-phenyl-4-(phenylamino)carbonyl-1h-pyrrole-1-heptanoic acid esters with calcium hydroxide
CA 2427255 A1 · Owner: Lifshitz, Revital · Inventors: Lidor-Hadas, Ramy; Lifshitz, Revital; Niddam, Valerie
Overview
Its claims, description and drawings are in the Canadian Patents Database.
Open the CIPO recordAbstract From the Canadian patent
The present invention provides a process for preparing atorvastatin hemicalcium from an atorvastatin ester derivative with calcium hydroxide. The process is conveniently incorporated into a process for preparing atorvastatin hemi-calcium from an acetonide protected ester protected .beta..delta.-, dihydroxy heptanoic acid precursor compound by a first acid hydrolysis step followed by base hydrolysis with calcium hydroxide. The latter process may be performed as a one-pot process.
Read the whole patent
Listed from its CIPO record in Patent Yard's archive of Canadian patents past their term. Its claims, description and drawings are in the CIPO record and on Google Patents, and the Claude kit works from them.
Why it's free to use
- Filed October 24, 2001. No grant is recorded for it in Canada; had it been granted, its 20-year term would have ended October 24, 2021.
- A certificate of supplementary protection adds at most two years for a drug, so even that would have ended by October 24, 2023.
- We check Canadian rights only. A patent in its family in another country could still be in force: check its family on Google Patents.
Timeline
Timeline From CIPO dates
Sources & verification
Official CIPO records
Everything on this page comes from the CIPO record linked above. Contains information licensed under the Open Government Licence – Canada.