Selective maxi-k- potassium channel openers functional under conditions of high intracellular calcium concentration, methods and uses thereof
CA 2425771 A1 · Owner: Gribkoff, Valentin K. · Inventors: Yeola, Sarita W.; Post-Munson, Debra J.; Gribkoff, Valentin K.
Overview
Its claims, description and drawings are in the Canadian Patents Database.
Open the CIPO recordAbstract From the Canadian patent
The present invention describes calcium sensitive and selective maxi-K potassium channel opener/activator compounds that function to open maxi-K channels under conditions of high intracellular calcium concentrations and , which do not significantly affect the opening of maxi-K channel proteins under conditions of low or physiologically normal intracellular calcium concentrations. Methods of assaying for and using such compounds are also provided. According to the invention, whole cell voltage patch-clamp studies newly demonstrated that the ability of opener compounds e.g. fluoro-, oxindoles and chloro-oxindoles to open maxi-K channels was sensitive to the intracellular ca2+ …
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Listed from its CIPO record in Patent Yard's archive of Canadian patents past their term. Its claims, description and drawings are in the CIPO record and on Google Patents, and the Claude kit works from them.
Why it's free to use
- Filed October 12, 2001. No grant is recorded for it in Canada; had it been granted, its 20-year term would have ended October 12, 2021.
- A certificate of supplementary protection adds at most two years for a drug, so even that would have ended by October 12, 2023.
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Everything on this page comes from the CIPO record linked above. Contains information licensed under the Open Government Licence – Canada.