Combination of amines and vanadium (iv)/(v) compounds for the treatment and/or prevention of diabetes mellitus

Abstract From the Canadian patent

Combinations including vanadium (IV)/(V) compounds and pharmaceutically acceptable amines selected from amongst the group of semicarbazide-sensitive amine oxidase substrates (SSAO) are imitators of insulin. The preferred vanadium (IV)/(V) compounds are vanadyl salts vanadyl complexes and vanadates , (for example sodium orthovanadate ). The preferred amines are tyramine and benzylamine. As a result of a synergy between the vanadium compound and the amine disclosed herein, an effective concentration of vanadate in said combination is lower than the one corresponding to vanadate alone. Consequently, the combination has a much lower toxicity than the vanadium compound alone, as is …