Immunotoxins
CA 2424255 A1 · Owner: Waibel, Robert · Inventors: Stahel, Rolf A.; Di Paolo, Claudio; Pluckthun, Andreas
Overview
Its claims, description and drawings are in the Canadian Patents Database.
Open the CIPO recordAbstract From the Canadian patent
Ep-CAM is a tumor-associated antigen overexpressed in many solid tumors but shows limited, expression in normal epithelial tissues. To exploit this favorable expression pattern for targeted, cancer therapy an Ep-CAM-specific recombinant immunotoxin was developed and its antitumor, activity investigated. The immunotoxin 4D5MOCB-ETA was developed by genetically fusing a, truncated form of ETA (ETA252-608KDEL) to the highly stable humanized scFv 4D5MOCB. Cytotoxicity of 4D5MOCB-ETA was measured in cell growth and leucine incorporation assays in, vitro Tumor localization and antitumor activity were assessed in athymic mice bearing, established human tumor xenografts. Fusion of the toxin …
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Listed from its CIPO record in Patent Yard's archive of Canadian patents past their term. Its claims, description and drawings are in the CIPO record and on Google Patents, and the Claude kit works from them.
Why it's free to use
- Filed March 26, 2003. No grant is recorded for it in Canada; had it been granted, its 20-year term would have ended March 26, 2023.
- A certificate of supplementary protection adds at most two years for a drug, so even that would have ended by March 26, 2025.
- We check Canadian rights only. A patent in its family in another country could still be in force: check its family on Google Patents.
Timeline
Timeline From CIPO dates
Sources & verification
Official CIPO records
Everything on this page comes from the CIPO record linked above. Contains information licensed under the Open Government Licence – Canada.