Induction of exon skipping in eukaryotic cells
CA 2423044 C · Owner: Van Deutekom, Judith Christina Theodora · Inventors: Van Ommen, Garrit-Jan Boudewijn; Van Deutekom, Judith Christina Theodora; Den Dunnen, Johannes Theodorus
Overview
Its claims, description and drawings are in the Canadian Patents Database.
Open the CIPO recordAbstract From the Canadian patent
The present invention provides a method for at least in part decreasing the production of an aberrant protein in a cell said cell comprising pre-mRNA , comprising exons coding for said protein by inducing so-called exon skipping , in said cell. Exon-skipping results in mature mRNA that does not contain the skipped exon which leads to an altered product if said exon codes for amino acids. Exon skipping is performed by providing a cell with an agent capable of specifically inhibiting an exon inclusion signal for instance an exon , recognition sequence of said exon. Said exon inclusion signal can be interfered with by a nucleic acid comprising complementarity to a part of said exon. Said …
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Listed from its CIPO record in Patent Yard's archive of Canadian patents past their term. Its claims, description and drawings are in the CIPO record and on Google Patents, and the Claude kit works from them.
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- Filed September 21, 2001 and granted August 23, 2016. A Canadian patent filed from October 1, 1989 lasts 20 years from filing, so its term ended September 21, 2021.
- A certificate of supplementary protection adds at most two years for a drug, so even that would have ended by September 21, 2023.
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