Method for determining the degree of methylation of defined cytosines in genomic dna in the sequence context 5'-cpg-3'
CA 2420840 A1 · Owner: Epigenomics Ag · Inventors: Piepenbrock, Christian; Olek, Alexander; Gutig, David
Overview
Its claims, description and drawings are in the Canadian Patents Database.
Open the CIPO recordAbstract From the Canadian patent
The invention relates to a method for detecting the degree of methylation of a defined cytosine in the sequence context 5ï-CpG-3ï of a genomic DNA sample. The first stage involves chemically treating the genomic DNA in such a way that the cytosine bases, but not the 5-methylcytosine bases are converted , into uracil. Parts of the genomic DNA containing the defined cytosine are then amplified. The amplified parts are given a detectable mark and the extent of the hybridisation of the amplified parts on the two classes of oligonucleotides is then determined by detecting the mark of the amplified parts. The degree of methylation of the defined cytosine in the genomic DNA sample can be …
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Listed from its CIPO record in Patent Yard's archive of Canadian patents past their term. Its claims, description and drawings are in the CIPO record and on Google Patents, and the Claude kit works from them.
Why it's free to use
- Filed September 1, 2001. No grant is recorded for it in Canada; had it been granted, its 20-year term would have ended September 1, 2021.
- A certificate of supplementary protection adds at most two years for a drug, so even that would have ended by September 1, 2023.
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Everything on this page comes from the CIPO record linked above. Contains information licensed under the Open Government Licence – Canada.