Microparticle compositions and methods for the manufacture thereof

Abstract From the Canadian patent

Microparticles with adsorbed complexes of macromolecule and detergent methods , of making such microparticles and uses thereof, are disclosed. The , microparticles comprise a polymer such as a poly(.alpha.-hydroxy acid), a polyhydroxy butyric acid, a polycaprolactone a polyorthoester, a , polyanhydride, and the like and are formed using cationic, anionic or , nonionic detergents. The surfaces of the microparticles have absorbed thereon a complex of biologically active macromolecules such as nucleic acids, polypeptides, antigens and adjuvants, and a detergent. Preferred polymers are poly(D,L-lactide-co-glycolides), more preferably those having a lactide/glycolide molar ratio ranging from …