Oxazolyl-aryloxyacetic acid derivatives and their use as ppar agonists

Abstract From the Canadian patent

Compounds represented by the following structural formula (I) and , pharmaceutically acceptable salts solvates and hydrates thereof, wherein R1 is an unsubstituted or substituted aryl heteroaryl, cycloalkyl, aryl-alkyl, heteroaryl-alkyl or cycloalkyl-alkyl R2 is H, alkyl or haloalkyl, the , polymethylene chain (II) is saturated or may contain a carbon-carbon double bond, while n is 2, 3, 4, W is O or S, Y is an unsubsituted or substituted phenylene, naphthylene or 1, 2, 3, 4 tetrahydronaphthylene R3 is H, alkyl or , haloalkyl. R4 is H alkyl, haloalkyl or a substituted or unsubstituted benzyl are useful for modulating a peroxisome proliferator activated receptor particularly in the …