Amino acid-derived cyclic phosphonamides and methods of synthesizing the same

Abstract From the Canadian patent

New phosphonamide compounds and methods of forming those compounds are provided. In one embodiment, the inventive methods comprise subjecting an opened-ring phosphonamide template to a ring-closing metathesis reaction in the presence of a ring-closing catalyst (e.g. a Grubbs catalyst) to yield a phosphonamide. In another embodiment, the inventive methods comprise reacting a template structure with a phosphorus (III) compound to yield the phosphonamide. Advantageously, in either embodiment the template structures , can be provided with a wide array of functional groups (e.g. amino acid side chains, peptides) chosen to provide particular properties to the compound.