Cyclic oxyguanidine pyrazinones as protease inhibitors

Abstract From the Canadian patent

Cyclic oxyguanidine pyrazinone compounds are described including compounds of , the Formula (I): wherein R3 R4, R5, W, and A are as set forth in the specidification, as well as hydrates, solvates or pharmaceutically acceptable salts thereof. The compounds of the invention are potent inhibitors of protease, especially trypsin-like serine proteases such as chymotripsin, trypsin, thrombin plasmin and factor Xa. Certain of the compounds exhibit antithrombotic activity via direct, selective inhibition of trombin. Compositions for inhibiting loss of blood platelas inhibiting formation of , blood platelet aggregates inhibiting formation of fibrin, inhibiting thrombus formation, and …