Piperidine compounds for use as ccr-3 inhibitors

Abstract From the Canadian patent

Compounds of formula (I) in free or salt form where Ar1 is phenyl substituted , by one or more halogen atoms Ar2 is phenyl or naphthyl which is unsubstituted or substituted by one or more substituents selected from halogen cyano, hydroxy, nitro, C1-C8-alkyl, C1-C8-haloalkyl C1-C8-alkoxy or C1-C8-, alkoxycarbonyl R1 is hydrogen or C1-C8-alkyl optionally substituted by hydroxy, C1-C8-alkoxy, acyloxy, N(R2)R3 halogen, carboxy, C1-C8-, alkoxycarbonyl -CON(R4)R5 or by a monovalent cyclic organic group R2 and R3 , are each independently hydrogen or C1-C8-alkyl or R2 is hydrogen and R3 is , acyl or -SO2R6 or R2 and R3 together with the nitrogen atom to which they are attached denote a 5- or …