Enzyme-cleavable prodrug compounds
CA 2411660 C · Owner: Yarranton, Geoffrey T. · Inventors: Trouet, Andre; Yarranton, Geoffrey T.; Pickford, Lesley B.
Overview
Its claims, description and drawings are in the Canadian Patents Database.
Open the CIPO recordAbstract From the Canadian patent
The prodrug of the invention is a modified form of a therapeutic agent and comprises a therapeutic agent, an oligopeptide a stabilizing group and, optionally, a linker group. The prodrug is cleavable by the enzyme Thimet oligopeptidase, or TOP. Also disclosed are methods of designing prodrugs by utilizing TOP-cleavage sequences within the conjugate and methods of treating patients with prodrugs of the invention.
Read the whole patent
Listed from its CIPO record in Patent Yard's archive of Canadian patents past their term. Its claims, description and drawings are in the CIPO record and on Google Patents, and the Claude kit works from them.
Why it's free to use
- Filed June 11, 2001 and granted March 1, 2011. A Canadian patent filed from October 1, 1989 lasts 20 years from filing, so its term ended June 11, 2021.
- A certificate of supplementary protection adds at most two years for a drug, so even that would have ended by June 11, 2023.
- We check Canadian rights only. A patent in its family in another country could still be in force: check its family on Google Patents.
Timeline
Timeline From CIPO dates
Sources & verification
Official CIPO records
Everything on this page comes from the CIPO record linked above. Contains information licensed under the Open Government Licence – Canada.