Method for preparing an r- or s-form of alpha-substituted heterocyclic carboxylic acid and a counter enantiomeric form of alpha-substituted heterocyclic carboxylic acid ester thereto using enzyme
CA 2410441 A1 · Owner: Lim, Sang-Chul · Inventors: Lim, Sang-Chul; Lim, Jong-Ho; Uhm, Ki-Nam
Overview
Its claims, description and drawings are in the Canadian Patents Database.
Open the CIPO recordAbstract From the Canadian patent
Disclosed is a method for preparing an R- or S-forms of alpha-substituted heterocyclic carboxylic acid (alpha-HCCA) and a counter enantiomeric form of alpha-substituted heterocyclic carboxylic acid ester thereto by use of an enzyme. A racemic alpha-HCCA is reacted with alcohol to give a racemic alpha- HCCA ester, which is then brought into contact with an enzyme with enantioselectivity, whereby either R-form or S-form of the racemate is hydrolyzed. Extraction with an organic solvent can obtain enantiomers of the alpha-HCCA ester. Thus, a certain enantiomeric form of alpha-HCCA and a counter enantiomeric form of alpha-HCCA ester thereto respectively can be , prepared with high optical …
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Listed from its CIPO record in Patent Yard's archive of Canadian patents past their term. Its claims, description and drawings are in the CIPO record and on Google Patents, and the Claude kit works from them.
Why it's free to use
- Filed May 25, 2001. No grant is recorded for it in Canada; had it been granted, its 20-year term would have ended May 25, 2021.
- A certificate of supplementary protection adds at most two years for a drug, so even that would have ended by May 25, 2023.
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