Methods for refolding proteins containing free cysteine residues
CA 2408851 C · Owner: Doherty, Daniel H. · Inventors: Rosendahl, Mary S.; Doherty, Daniel H.; Cox, George N.
Overview
Its claims, description and drawings are in the Canadian Patents Database.
Open the CIPO recordAbstract From the Canadian patent
The present invention relates to novel methods for making and refolding insoluble or aggregated proteins having free cysteines in which a host cell expressing the protein is exposed to a cysteine blocking agent. The soluble refolded proteins produced by the novel methods can then be modified to increase their effectiveness. Such modifications include attaching a PEG moiety to form PEGylated proteins.
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Listed from its CIPO record in Patent Yard's archive of Canadian patents past their term. Its claims, description and drawings are in the CIPO record and on Google Patents, and the Claude kit works from them.
Why it's free to use
- Filed May 16, 2001 and granted July 12, 2011. A Canadian patent filed from October 1, 1989 lasts 20 years from filing, so its term ended May 16, 2021.
- A certificate of supplementary protection adds at most two years for a drug, so even that would have ended by May 16, 2023.
- We check Canadian rights only. A patent in its family in another country could still be in force: check its family on Google Patents.
Timeline
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Sources & verification
Official CIPO records
Everything on this page comes from the CIPO record linked above. Contains information licensed under the Open Government Licence – Canada.