Gamma secretase substrates and in vitro assays
CA 2408003 A1 · Owner: Huang, Qian · Inventors: Li, Yueming; Huang, Qian; Gardell, Stephen
Overview
Its claims, description and drawings are in the Canadian Patents Database.
Open the CIPO recordAbstract From the Canadian patent
The present invention features .gamma.-secretase substrates andin vitro assays for measuring .gamma.-secretase activity employing such substrates. The .gamma.-secretase substrates described herein contain a hydrophilic polypeptide moiety covalently joined to the carboxyl terminus of a .beta.-CTF domain. A ".beta.-CTF domain" is a polypeptide that can be cleaved by .gamma.secretase and which approximates the C-terminal fragment (amino acids 596-695) of APP produced after cleavage of APP by a .beta.-secretase or is a , functional derivative thereof.
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Listed from its CIPO record in Patent Yard's archive of Canadian patents past their term. Its claims, description and drawings are in the CIPO record and on Google Patents, and the Claude kit works from them.
Why it's free to use
- Filed April 25, 2001. No grant is recorded for it in Canada; had it been granted, its 20-year term would have ended April 25, 2021.
- A certificate of supplementary protection adds at most two years for a drug, so even that would have ended by April 25, 2023.
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Timeline
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Sources & verification
Official CIPO records
Everything on this page comes from the CIPO record linked above. Contains information licensed under the Open Government Licence – Canada.