Indole derivatives with vascular damaging activity

Abstract From the Canadian patent

The invention provides a compound of Formula (I) wherein: R1 and R2 are independently selected from hydrogen, halogen -CN, a hydrocarbyl group or a , group of Formula (II); wherein W is aryl or a heterocyclic group R4 is , independently selected from hydrogen halogen, -OH, amino, alkanoylamino, -, OPO3H2 or a hydrocarbyl group, wherein the amino group is optionally substituted by an amino acid residue and the hydroxy group is optionally esterified or two R4 groups together form an optionally substituted cyclic or heterocyclic group; X is selected from $M(y) S+- +-O-+, -+S(O)+-, -+S(O2)+- , and -+NH--; p is an integer from 0 to 4; and q is an integer from 1 to 4; R3 and R10 are …