Methods and compositions for eliciting an immune response

Abstract From the Canadian patent

The invention provides methods and compositions useful for inducing or enhancing an immune response in a human or non-human animal. In an embodiment the method involves administering an antigen-presenting cell chemotaxin such , as a chemokine polypeptide or variant thereof optionally with administration , of an antigen. In some embodiments the chemokine or variant is chemotactic for dendritic cells and/or macrophages but not chemotactic for one or more of neutrophils, T-lymphocytes, monocytes, or eosinophils. In an embodiment the , chemokine or variant is a chemotaxin for immature but not mature dendritic cells.