Fluorescence assay for gamma-secretase activity and inhibitors
CA 2405332 A1 · Owner: Vinitsky, Alexander · Inventors: Roberts, Susan B.; Vinitsky, Alexander; Smith, David W.
Overview
Its claims, description and drawings are in the Canadian Patents Database.
Open the CIPO recordAbstract From the Canadian patent
The present invention provides an isolated functionally-active protein that , catalyzes cleavage of a gamma-secretase substrate. The functional activity of the isolated protein suggests that the isolated protein includes gammasecretase. In one embodiment, the isolated gamma-secretase protein is associated with PS1. The present invention also relates to homogeneous methods for monitoring cleavage of .beta.-amyloid precursor protein (.beta.APP) by gamma-secretase, wherein the steps of isolating and retrieving cleavage products have been eliminated. Cleavage can be detected by binding a pair of fluorescent adducts to the gamma-cleaved .beta.APP fragment. Preferably a , first fluorescent …
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Listed from its CIPO record in Patent Yard's archive of Canadian patents past their term. Its claims, description and drawings are in the CIPO record and on Google Patents, and the Claude kit works from them.
Why it's free to use
- Filed March 30, 2001. No grant is recorded for it in Canada; had it been granted, its 20-year term would have ended March 30, 2021.
- A certificate of supplementary protection adds at most two years for a drug, so even that would have ended by March 30, 2023.
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Timeline
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Sources & verification
Official CIPO records
Everything on this page comes from the CIPO record linked above. Contains information licensed under the Open Government Licence – Canada.