A method for in vitro molecular evolution of antibody function
CA 2402240 C · Owner: Carlsson, Roland · Inventors: Carlsson, Roland; Soderlind, Eskil; Ohlin, Mats
Overview
Its claims, description and drawings are in the Canadian Patents Database.
Open the CIPO recordAbstract From the Canadian patent
The present invention provides a method for producing a polynucleotide sequence encoding an antibody variable domain the variable domain comprising , complementarity-determining regions (CDRs) located within a selected framework (the 'master framework'), the method comprising the steps of (a) providing at least one nucleic acid molecule encoding one or more CDRs and associated framework regions (the 'original framework') (b) amplifying at least one CDR-, encoding portion of the nucleic acid molecule(s) of step (a) using one or more pairs of oligonucleotides as amplification primers and (c) assembling a polynucleotide sequence encoding an antibody variable domain by combining the …
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Listed from its CIPO record in Patent Yard's archive of Canadian patents past their term. Its claims, description and drawings are in the CIPO record and on Google Patents, and the Claude kit works from them.
Why it's free to use
- Filed April 4, 2001 and granted February 28, 2012. A Canadian patent filed from October 1, 1989 lasts 20 years from filing, so its term ended April 4, 2021.
- A certificate of supplementary protection adds at most two years for a drug, so even that would have ended by April 4, 2023.
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Everything on this page comes from the CIPO record linked above. Contains information licensed under the Open Government Licence – Canada.