Processes for preparing clarithromycin and clarithromycin intermediate, essentially oxime-free clarithromycin, and pharmaceutical composition comprising the same
CA 2401571 A1 · Owner: Lifshitz, Igor · Inventors: Avrutov, Ilya; Kogan, Elizabeth; Lifshitz, Igor
Overview
Its claims, description and drawings are in the Canadian Patents Database.
Open the CIPO recordAbstract From the Canadian patent
The present invention relates to processes for preparing protected silylated clarithromycin oxime, preferably 6-O-methy-2',4"-bis(trimethylsilyl)erythromycin A 9-O-(2-methoxyprop-2-yl)oxime("S-MOP oxime") and for , converting protected silylated clarithromycin oxime preferably S-MOP oxime, to clarithromycin. Processes for preparing protected silylated clarithromycin oxime according to the present invention include reacting a silyl oxime , derivative with methylating agent in the presence of at least one solvent and a base, where the solvent comprises methyl tertbutyl ether. Processes for converting protected silylated clarithromycin oxime to clarithromycin according to the present …
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Listed from its CIPO record in Patent Yard's archive of Canadian patents past their term. Its claims, description and drawings are in the CIPO record and on Google Patents, and the Claude kit works from them.
Why it's free to use
- Filed December 15, 2000. No grant is recorded for it in Canada; had it been granted, its 20-year term would have ended December 15, 2020.
- A certificate of supplementary protection adds at most two years for a drug, so even that would have ended by December 15, 2022.
- We check Canadian rights only. A patent in its family in another country could still be in force: check its family on Google Patents.
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Official CIPO records
Everything on this page comes from the CIPO record linked above. Contains information licensed under the Open Government Licence – Canada.