A method for generating hypermutable plants
CA 2400664 C · Owner: Johns Hopkins University · Inventors: Vogelstein, Bert; Nicolaides, Nicholas C.; Grasso, Luigi
Overview
Its claims, description and drawings are in the Canadian Patents Database.
Open the CIPO recordAbstract From the Canadian patent
Blockade of mismatch repair in a plant can lead to hypermutation and a new genotype and/or phenotype. One approach used to generate hypermutable plants is through the expression of dominant negative alleles of mismatch repair genes in transgenic plants or derived cells. By introducing these genes into cells and transgenic plants, new cell lines and plant varieties with novel and useful properties can be prepared more efficiently than by relying on the natural rate of mutation. Moreover methods to , inhibit the expression and activity of endogenous plant MMR genes and their encoded products are also useful to generate hypermutable plants.
Read the whole patent
Listed from its CIPO record in Patent Yard's archive of Canadian patents past their term. Its claims, description and drawings are in the CIPO record and on Google Patents, and the Claude kit works from them.
Why it's free to use
- Filed December 28, 2000 and granted March 1, 2011. A Canadian patent filed from October 1, 1989 lasts 20 years from filing, so its term ended December 28, 2020.
- A certificate of supplementary protection adds at most two years for a drug, so even that would have ended by December 28, 2022.
- We check Canadian rights only. A patent in its family in another country could still be in force: check its family on Google Patents.
Timeline
Timeline From CIPO dates
Sources & verification
Official CIPO records
Everything on this page comes from the CIPO record linked above. Contains information licensed under the Open Government Licence – Canada.