Cytochrome p450rai-2 and related proteins
CA 2396511 A1 · Owner: White, Jay A. · Inventors: Jones, Glenville; White, Jay A.; Petkovich, Martin P.
Overview
Its claims, description and drawings are in the Canadian Patents Database.
Open the CIPO recordAbstract From the Canadian patent
The present invention provides a novel all-trans-RA inducible all-trans-RA metabolizing cytochrome P450, P450RAI-2 that is predominantly expressed in , the brain cerebellum in particular. Human P450RAI-2 show 42 % amino acid identity to human P450RAI-1 and when transfected into COS-1 cells causes the rapid conversion of all-trans-RA into more polar metabolites including the inactive products 4-oxo-RA, 4-OH-RA and 18-OH-RA. P450RAI-2 as with P450RAI-, 1, is also inducible in certain cultured cell lines exposed to all-trans-RA. Methods for and uses of the new polynucleotide polypeptide, fragments thereof , and inhibitors thereof include the treatment of dermatological disorders and …
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Listed from its CIPO record in Patent Yard's archive of Canadian patents past their term. Its claims, description and drawings are in the CIPO record and on Google Patents, and the Claude kit works from them.
Why it's free to use
- Filed December 15, 2000. No grant is recorded for it in Canada; had it been granted, its 20-year term would have ended December 15, 2020.
- A certificate of supplementary protection adds at most two years for a drug, so even that would have ended by December 15, 2022.
- We check Canadian rights only. A patent in its family in another country could still be in force: check its family on Google Patents.
Timeline
Timeline From CIPO dates
Sources & verification
Official CIPO records
Everything on this page comes from the CIPO record linked above. Contains information licensed under the Open Government Licence – Canada.