Novel steroid-activated nuclear receptors and uses therefor
CA 2394970 C · Owner: Evans, Ronald M. · Inventors: Blumberg, Bruce; Xie, Wen; Evans, Ronald M.
Overview
Its claims, description and drawings are in the Canadian Patents Database.
Open the CIPO recordAbstract From the Canadian patent
A novel nuclear receptor, termed the steroid and xenobiotic receptor (SXR) a , broad-specificity sensing receptor that is a novel branch of the nuclear receptor superfamily, has been discovered. SXR forms a heterodimer with RXR that can bind to and induce transcription from response elements present in steroid-inducible cytochrome P450 genes in response to hundreds of natural and synthetic compounds with biological activity including therapeutic steroids , as well as dietary steroids and lipids. Instead of hundreds of receptors one , for each inducing compound, the invention SXR receptors monitor aggregate levels of inducers to trigger production of metabolizing enzymes in a …
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Listed from its CIPO record in Patent Yard's archive of Canadian patents past their term. Its claims, description and drawings are in the CIPO record and on Google Patents, and the Claude kit works from them.
Why it's free to use
- Filed December 8, 2000 and granted February 3, 2015. A Canadian patent filed from October 1, 1989 lasts 20 years from filing, so its term ended December 8, 2020.
- A certificate of supplementary protection adds at most two years for a drug, so even that would have ended by December 8, 2022.
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Official CIPO records
Everything on this page comes from the CIPO record linked above. Contains information licensed under the Open Government Licence – Canada.