Process for the preparation of arylethanolamine derivatives having anti-obesity and anti-diabetic properties

Abstract From the Canadian patent

see formula IA) (see formula II) , A process for preparing arylethanoldiamines which are useful as agonists at , atypical beta-adrenoceptors, is described. The process involves preparation of a compound of , Formula (IA) or salt thereof : wherein R1 is an aryl pyridyl, thiazolyl, phenoxymethyl, or pyrimidyl group optionally substituted with: halogen, hydroxy C1-6alkoxy, C1-6alkyl, hydroxymethyl, trifluoromethyl -NR6R6, or NHSO2R6, where each R6 is hydrogen or , C1-4alkyl; R2 is hydrogen or C1-6alky; R3 is CO2R7 where R7 is hydrogen or C1- 6alkyl; R4 , and R5 are hydrogen, C1-6alkyl or -CO2C1-6alkyl; and Y is N or CH, comprising preparing amide of Formula (II) or salt thereof: wherein R1 …