Use of poly-nitroxyl-functionalized dendrimers as contrast enhancing agents in mri imaging of joints

Abstract From the Canadian patent

The image obtained by MR imaging of the joint of an animal including humans, is enhanced by injecting into the joint prior to the scan of an imaging enhancing amount of a nitroxyl functionalized dendrimer containing at least 6 nitroxyl terminal functional groups, e.g of Formula (I) wherein each R , independently is either a nitroxyl group of Formula (II) wherein X is an oxygen atom or two hydrogen atoms, R' is lower alkyl and R" is H or lower alkyl, or a group of Formula (III) wherein R'" is lower alkyl or a group of , Formula (IV): wherein each alkylene in Formulae (I) (III) and (IV) is a , bridging divalent alkylene group of 2-6 carbon atoms with 2-3 carbon atoms in the chain and R …