Pde10 cell-based assay and sequences
CA 2391117 A1 · Owner: Menniti, Frank Samuel · Inventors: Menniti, Frank Samuel; Lebel, Lorraine Ann; Strick, Christine Ann
Overview
Its claims, description and drawings are in the Canadian Patents Database.
Open the CIPO recordAbstract From the Canadian patent
The invention features a method of creeping for an agent that inhibits intracellular phosphodiesterase 10A activity comprising administering an , agent to striatal medium spiny neurons and submaximally activating adenylate cyclase; administering an agent to striatal medium spiny neurons and submaximally activating guanylate cyclase, measuring cAMP generation and cGMP generation in the cells, and calculating the cAMP EC200 and the cGMP EC200 wherein the , agent, is identified as a PDE10A inhibitor if the ratio of cAMP EC200/ cGMP EC200 is comparable to the ratio produced by administration of papaverine under the same, assay conditions. Also featured are rat PDE10A polynucleotide and …
Read the whole patent
Listed from its CIPO record in Patent Yard's archive of Canadian patents past their term. Its claims, description and drawings are in the CIPO record and on Google Patents, and the Claude kit works from them.
Why it's free to use
- Filed July 29, 2002. No grant is recorded for it in Canada; had it been granted, its 20-year term would have ended July 29, 2022.
- A certificate of supplementary protection adds at most two years for a drug, so even that would have ended by July 29, 2024.
- We check Canadian rights only. A patent in its family in another country could still be in force: check its family on Google Patents.
Timeline
Timeline From CIPO dates
Sources & verification
Official CIPO records
Everything on this page comes from the CIPO record linked above. Contains information licensed under the Open Government Licence – Canada.