Resolution of intermediates in the synthesis of substantially pure bicalutamide
CA 2389100 A1 · Owner: Ekwuribe, Nnochiri N. · Inventors: Ekwuribe, Nnochiri N.; James, Kenneth D.
Overview
Its claims, description and drawings are in the Canadian Patents Database.
Open the CIPO recordAbstract From the Canadian patent
A method of preparing a substantially pure enantiomer of an acylanilide such as Casodex® (bicalutamide) and/or its derivatives includes resolving an intermediate compound having the structure of Formula (I) wherein: R1 is , alkyl or haloalkyl having up to 4 carbons; R2 is alkyl having up to 6 carbon atoms; R3 is a direct link or alkyl having up to 6 carbon atoms; R4 is alkyl alkenyl, hydroxyalkyl or cycloalkyl each of up to 6 carbons; or R4 is phenyl which bears one, two or three substituents independently selected from hydrogen, halogen, nitro, carboxy, carbamoyl and cyano and alkyl, alkoxy, alkanoyl, alkylthio alkylsulphinyl, alkylsulphonyl, perfluoroalkyl perfluoroalkylthio, …
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Listed from its CIPO record in Patent Yard's archive of Canadian patents past their term. Its claims, description and drawings are in the CIPO record and on Google Patents, and the Claude kit works from them.
Why it's free to use
- Filed October 25, 2000. No grant is recorded for it in Canada; had it been granted, its 20-year term would have ended October 25, 2020.
- A certificate of supplementary protection adds at most two years for a drug, so even that would have ended by October 25, 2022.
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Timeline
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Sources & verification
Official CIPO records
Everything on this page comes from the CIPO record linked above. Contains information licensed under the Open Government Licence – Canada.