Methods of asymmetrically synthesizing enantiomers of casodex, its derivatives and intermediates thereof
CA 2387570 A1 · Owner: Ekwuribe, Nnochiri · Inventors: Ekwuribe, Nnochiri
Overview
Its claims, description and drawings are in the Canadian Patents Database.
Open the CIPO recordAbstract From the Canadian patent
A method of synthesizing pure enantiomers of acylanalides such as Casodex® (bicalutamide) and its derivatives includes contacting a compound having a ring structure that, when opened, provides a substituent having the structure of Formula (I), with a compound having a structure of the Formula (II): R7-R6- X1H, under conditions sufficient to provide a compound having the structure of Formula (III) wherein X2 is oxygen, sulfur sulphinyl (-SO-), sulphonyl (-SO2-, ), imino (-NH-) oxidized imino alkylimino (-NR8-) where R8 is alkyl having up to 6 carbon atoms, or oxidized alkylimino. The method further includes treating the compound of Formula (III) under conditions sufficient to provide …
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Listed from its CIPO record in Patent Yard's archive of Canadian patents past their term. Its claims, description and drawings are in the CIPO record and on Google Patents, and the Claude kit works from them.
Why it's free to use
- Filed October 18, 2000. No grant is recorded for it in Canada; had it been granted, its 20-year term would have ended October 18, 2020.
- A certificate of supplementary protection adds at most two years for a drug, so even that would have ended by October 18, 2022.
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Official CIPO records
Everything on this page comes from the CIPO record linked above. Contains information licensed under the Open Government Licence – Canada.