Genetically engineered cell lines, and their uses, in particular for neurotoxicity testing

Abstract From the Canadian patent

The present invention relates to genetically engineered cell lines and to , their uses, in particular in processes for screening the developmental or postdevelopmental neurotoxicity of endogenous or exogenous factors including , drugs and other chemicals, also at low-level exposure for screening , pharmaceutically active molecules useful as drugs for the treatment of pathologies involving an abnormal inhibition or activation of cell death and , for mechanistic studies, the said cell lines being genetically transformed with a nucleotide sequence coding for the p53 protein or a nucleotide sequence coding for the bcl-2 protein, and a nucleotide sequence controlling the level of expression …