Chiral ligands, transition-metal complexes thereof and uses thereof in asymmetric reactions

Abstract From the Canadian patent

Chiral ligands and transition metal complexes based on such chiral ligands useful in asymmetric catalysis are disclosed. The chiral ligands include phospholanes, P, N ligands, N, N ligands biphenols, and chelating phosphines. , The ferrocene-based irridium (R,R)-f-binaphane complex reduces imines to the corresponding amines with 95-99.6 % enantioselectivity and reduces .beta.substituted-.alpha.-arylenamides with 95 % enantioselectivity. The transition metal complexes of the chiral ligands are useful in asymmetric reactions such as asymmetric hydrogenation of imines, asymmetric hydride transfer reactions hydrosilylation, hydroboration, hydrovinylation hydroformylation, allylic , …