Process and intermediates for preparing escitalopram
CA 2381341 A1 · Owner: Tse, Hoi Lun Allan · Inventors: Tse, Hoi Lun Allan
Overview
Its claims, description and drawings are in the Canadian Patents Database.
Open the CIPO recordAbstract From the Canadian patent
The antidepressant drug Escitalopram is prepared from 5-bromophthalide via the diol intermediate (4-bromo-2-(hydroxymethyl)phenyl)-(4-fluorophenyl)methanol. The, racemic diol intermediate is converted to an enantiomerically enriched form by first, converting the diol to a monoester intermediate and then reacting the monoester, intermediate with an optically active acid most preferably (+~di-p-toluoyl , tartaric acid, to form a salt. The salt is then crystallized to recover an enantiomerically, enriched, crystalline form thereof. The monoester intermediate is preferably formed, by reacting the racemic diol intermediate with an acid or a reactive acid derivative, which, in a …
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Listed from its CIPO record in Patent Yard's archive of Canadian patents past their term. Its claims, description and drawings are in the CIPO record and on Google Patents, and the Claude kit works from them.
Why it's free to use
- Filed April 9, 2002. No grant is recorded for it in Canada; had it been granted, its 20-year term would have ended April 9, 2022.
- A certificate of supplementary protection adds at most two years for a drug, so even that would have ended by April 9, 2024.
- We check Canadian rights only. A patent in its family in another country could still be in force: check its family on Google Patents.
Timeline
Timeline From CIPO dates
Sources & verification
Official CIPO records
Everything on this page comes from the CIPO record linked above. Contains information licensed under the Open Government Licence – Canada.