Process for the preparation of naproxene nitroxyalkylesters
CA 2380116 C · Owner: Nicox Science Ireland · Inventors: Castaldi, Graziano; Tarquini, Antonio; Oldani, Erminio
Overview
Its claims, description and drawings are in the Canadian Patents Database.
Open the CIPO recordAbstract From the Canadian patent
A process for obtaining nitroxyalkylesters of the 2-(S)-(6-methoxy-2-naphthyl)propanoic acid having an enantiomeric excess higher than or equal to 95 % preferably higher than or equal to 98 % characterized in that an halide of , the 2-(S)-(6-methoxy-2-naphthyl)-propanoic acid of formula A-Hal wherein A is , the acid acyl residue, is reacted in an inert organic solvent with an aliphatic nitroxyalkanol HO-Y-ONO2, wherein Y is a C2-C20 alkylene or a cycloalkylene from 3 to 8 carbon atoms or an alkylene as defined containing a cycloalkylene as defined, in the presence of an inorganic base.
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Listed from its CIPO record in Patent Yard's archive of Canadian patents past their term. Its claims, description and drawings are in the CIPO record and on Google Patents, and the Claude kit works from them.
Why it's free to use
- Filed July 27, 2000 and granted July 5, 2011. A Canadian patent filed from October 1, 1989 lasts 20 years from filing, so its term ended July 27, 2020.
- A certificate of supplementary protection adds at most two years for a drug, so even that would have ended by July 27, 2022.
- We check Canadian rights only. A patent in its family in another country could still be in force: check its family on Google Patents.
Timeline
Timeline From CIPO dates
Sources & verification
Official CIPO records
Everything on this page comes from the CIPO record linked above. Contains information licensed under the Open Government Licence – Canada.