Hydroxamic acid compounds useful as matrix metalloproteinase inhibitors

Abstract From the Canadian patent

Compounds of formula (I), are useful for inhibiting matrix metalloproteinase enzymes in animals, and as such, prevent and treat diseases resulting from the breakdown of connective tissues. Also disclosed are methods for the preparation of such compounds, pharmaceutical compositions including the same and methods of treating diseases in which matrix metalloproteinases are involved including multiple sclerosis, atherosclerotic plaque rupture restenosis, aortic aneurysm, heart failure periodontal disease, corneal , ulceration burns, decubital ulcers, chronic ulcers or wounds cancer , metastasis, tumor angiogenesis osteoporosis, rheumatoid or osteoarthritis renal disease, left ventricular …